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The synergistic rate of DTX combined with azoles. (A) Interaction profile of DTX combined with POS, <t>ITC,</t> VOR, and ISA against E. dermatitidis ; (B) interaction profile of DTX combined with POS, <t>ITC,</t> VOR, and ISA against E. alcalophila ; (C) interaction profile of DTX combined with POS, ITC, VOR and ISA against A. niger . The synergism rate was calculated by dividing the number of strains exhibiting synergism by the total number of strains tested. S: synergy (FICI≤0.5); I: indifference (FICI from >0.5 to ≤4); A, antagonism (FICI of >4). DTX, docetaxel; ITR, <t>itraconazole;</t> VOR, voriconazole; POS, posaconazole; ISA, isavuconazole.
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The synergistic rate of DTX combined with azoles. (A) Interaction profile of DTX combined with POS, <t>ITC,</t> VOR, and ISA against E. dermatitidis ; (B) interaction profile of DTX combined with POS, <t>ITC,</t> VOR, and ISA against E. alcalophila ; (C) interaction profile of DTX combined with POS, ITC, VOR and ISA against A. niger . The synergism rate was calculated by dividing the number of strains exhibiting synergism by the total number of strains tested. S: synergy (FICI≤0.5); I: indifference (FICI from >0.5 to ≤4); A, antagonism (FICI of >4). DTX, docetaxel; ITR, <t>itraconazole;</t> VOR, voriconazole; POS, posaconazole; ISA, isavuconazole.
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The synergistic rate of DTX combined with azoles. (A) Interaction profile of DTX combined with POS, <t>ITC,</t> VOR, and ISA against E. dermatitidis ; (B) interaction profile of DTX combined with POS, <t>ITC,</t> VOR, and ISA against E. alcalophila ; (C) interaction profile of DTX combined with POS, ITC, VOR and ISA against A. niger . The synergism rate was calculated by dividing the number of strains exhibiting synergism by the total number of strains tested. S: synergy (FICI≤0.5); I: indifference (FICI from >0.5 to ≤4); A, antagonism (FICI of >4). DTX, docetaxel; ITR, <t>itraconazole;</t> VOR, voriconazole; POS, posaconazole; ISA, isavuconazole.
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The synergistic rate of DTX combined with azoles. (A) Interaction profile of DTX combined with POS, <t>ITC,</t> VOR, and ISA against E. dermatitidis ; (B) interaction profile of DTX combined with POS, <t>ITC,</t> VOR, and ISA against E. alcalophila ; (C) interaction profile of DTX combined with POS, ITC, VOR and ISA against A. niger . The synergism rate was calculated by dividing the number of strains exhibiting synergism by the total number of strains tested. S: synergy (FICI≤0.5); I: indifference (FICI from >0.5 to ≤4); A, antagonism (FICI of >4). DTX, docetaxel; ITR, <t>itraconazole;</t> VOR, voriconazole; POS, posaconazole; ISA, isavuconazole.
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The synergistic rate of DTX combined with azoles. (A) Interaction profile of DTX combined with POS, <t>ITC,</t> VOR, and ISA against E. dermatitidis ; (B) interaction profile of DTX combined with POS, <t>ITC,</t> VOR, and ISA against E. alcalophila ; (C) interaction profile of DTX combined with POS, ITC, VOR and ISA against A. niger . The synergism rate was calculated by dividing the number of strains exhibiting synergism by the total number of strains tested. S: synergy (FICI≤0.5); I: indifference (FICI from >0.5 to ≤4); A, antagonism (FICI of >4). DTX, docetaxel; ITR, <t>itraconazole;</t> VOR, voriconazole; POS, posaconazole; ISA, isavuconazole.
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The synergistic rate of DTX combined with azoles. (A) Interaction profile of DTX combined with POS, ITC, VOR, and ISA against E. dermatitidis ; (B) interaction profile of DTX combined with POS, ITC, VOR, and ISA against E. alcalophila ; (C) interaction profile of DTX combined with POS, ITC, VOR and ISA against A. niger . The synergism rate was calculated by dividing the number of strains exhibiting synergism by the total number of strains tested. S: synergy (FICI≤0.5); I: indifference (FICI from >0.5 to ≤4); A, antagonism (FICI of >4). DTX, docetaxel; ITR, itraconazole; VOR, voriconazole; POS, posaconazole; ISA, isavuconazole.

Journal: Frontiers in Microbiology

Article Title: In vitro study on synergistic antifungal effects of docetaxel combined with azoles against dematiaceous fungi and Aspergillus niger

doi: 10.3389/fmicb.2026.1832946

Figure Lengend Snippet: The synergistic rate of DTX combined with azoles. (A) Interaction profile of DTX combined with POS, ITC, VOR, and ISA against E. dermatitidis ; (B) interaction profile of DTX combined with POS, ITC, VOR, and ISA against E. alcalophila ; (C) interaction profile of DTX combined with POS, ITC, VOR and ISA against A. niger . The synergism rate was calculated by dividing the number of strains exhibiting synergism by the total number of strains tested. S: synergy (FICI≤0.5); I: indifference (FICI from >0.5 to ≤4); A, antagonism (FICI of >4). DTX, docetaxel; ITR, itraconazole; VOR, voriconazole; POS, posaconazole; ISA, isavuconazole.

Article Snippet: The experimental drugs, such as ITC (Cat. No. HY-17514, purity = 99.59%), POS (Cat. No. HY-17373, purity = 99.95%), and VOR (Cat. No. HY-76200, purity = 99.45%), were obtained from MedChemExpress (MCE), NJ, USA.

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